Mottled skin changes.

Marked regional endothelial dysfunction in mottled skin area in patients with severe infections

BACKGROUND Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized that the cutaneous hypoperfusion observed in the mottled area is related to regional endothelial dysfunction. METHODS This was a prospective, observational study in a medical ICU...

A clinical study of topical Pyratine 6 for improving the appearance of photodamaged skin.

OBJECTIVE Pyratine 6 has been shown to have antiaging effects in human skin cells. The purpose of this study is to determine the cosmetic efficacy and tolerance of topical Pyratine 6 (0.10%) over 12 weeks for improving the baseline clinical signs and symptoms of photodamaged facial skin. METHODS A single-arm longitudinal study with observations at 2, 4, 8, and 12 weeks was conducted. Forty he...

Mottled Lunulae in Nail Psoriasis: Report of Three Cases.

بررسی اثر منبع نوری پالسی پر قدرت (IPL) بر روند پیری ناشی از صدمه آفتاب (Photoaging

Background: Photo-damaged skin is characterized not only by wrinkles and creases but also by epidermal and dermal atrophy, rough skin texture, irregular pigmentation, talengiectasis , laxity and enlarged pores. There is growing interest in the development of noninvasive methods to treat photo-damaged skin. Intense Pulsed Light (IPL), a non-coherent, broadband, pulsed light source is effective i...

Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse.

Inbred mice bearing certain alleles at the Mottled locus have defects in connective tissue which result in weakness of skin and of blood vessels. Previous studies have established that cross-links in collagen and elastin are decreased in these animals due to impaired formation of lysine-derived aldehydes. Lysyl oxidase activity in extracts of skin is markedly lower in those prepared from affect...